Now showing items 41-45 of 45
Molecular mechanisms of conformational specificity: A study of Hox in vivo target DNA binding specificities and the structure of a Ure2p mutation that affects fibril formation rates
The fate of an individual cell, or even an entire organism, is often determined by minute, yet very specific differences in the conformation of a single protein species. Very often, proteins take on alternate folds or even ...
Keratinocyte as a model system for transcriptional control of epithelial homeostasis and carcinogenic transformation
Keratinocytes are specialized epithelial cells making up most of the stratified squamous epithelia of the mammalian epidermis and oral mucosa. In these epithelial tissues, the keratinocytes are arranged such that the ...
Self-assembling nanotubes consisting of aromatic oligoamide macrocycles as highly conducting transmembrane pores
The flow of ions into or out of a cell through channels is a specific and carefully regulated process that is vital for life. Although much knowledge has been gained about the transmembrane proteins that pass ions through ...
A guidance system for optical patient alignment during breast radiotherapy
Breast radiotherapy, particularly IMRT, involves large dose gradients and difficult patient positioning problems. A critical requirement for successful treatment is accurate reproduction of the patient's position assumed ...
Structural elucidation of cyclooxygenase enzymes provides insight into the specific stereochemistry of the cyclooxygenase reaction mechanism along with the formation of 15R cyclooxygenase products
Cyclooxygenase (COX) enzymes are heme containing enzymes that catalyze the conversion of Arachidonic (AA) to prostaglandin H 2 (PGH 2 ) during the committed step in prostanoid biosynthesis. This consists of two sequential ...