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Engineered Antibody Fragments Targeting Chemokine Receptors to Modulate Macrophage Phenotype for Tumor Inhibition
(State University of New York at Buffalo, 2019)
In Chapter I we give a perspective and comprehensive review on design principles of targeted nanocarriers with an emphasis on improving clinical translation. We discuss membrane fluidity and spatial control of ligand ...
Dynamics of Finite Phononic Crystals and Metamaterials
(State University of New York at Buffalo, 2019)
Phononic materials (PMs) are artificially engineered materials that exhibit a periodic variation in their mechanical or geometric properties which culminate in unprecedented bulk properties which are not readily available ...
Trauma, Dilemma, Language, and the Crisis of Narrative in the Works of Joseph Heller, Kurt Vonnegut, and Don Delillo
(State University of New York at Buffalo, 2019)
This dissertation explores war and terror-related traumas in post-WWII American novels to recognize particular histories that are outside the boundaries of language and representation and the frames of conventional narrative ...
Elucidating the Pharmacokinetics and Pharmacodynamics of Oxidative Phosphorylation Uncouplers for the Treatment of Obesity
(State University of New York at Buffalo, 2019)
Obesity continues to plague the population of the United States at an epidemic proportion. As many as 1 in 3 people in US are considered obese, and the current clinical treatment options are limited. The medical costs ...
A Study of Structure and Function at Neurotransmitter Binding Sites of Nicotinic Receptors
(State University of New York at Buffalo, 2019)
In 1961, Jacques Monod said, “I think I have discovered the second secret of life!”. This popular story was about “allosteric regulation”, which is apparently the biochemical alternative to the model of gene action (“first ...
Hsp60 Promotes Aggressive Prostate Cancer by Modulating Mitochondrial Function
(State University of New York at Buffalo, 2019)
Prostate cancer is the second most diagnosed cancer in American men and the third leading cause of cancer-related death in American men. Although the five-year survival rate for patients with androgen-sensitive prostate ...
Optimized Engineering Platform for the Generation of Recycling Therapeutic Antibodies
(State University of New York at Buffalo, 2019)
A new modality in antibody engineering has emerged in which the antigen affinity is designed to be pH dependent (PHD). In particular, the combination of high affinity binding at neutral pH with low affinity binding at ...
Health Information Exchanges: Impact on Healthcare Costs, Referral Networks, and Referral Decision Making Processes
(State University of New York at Buffalo, 2019)
Health Information Exchange (HIE) platforms have become an important part of the United States healthcare reform since the enactment of Health Information Technology for Economic and Clinical Health Act (Vest et al. 2010). ...
Representing 9/11: Intermediality, Plurality and Temporality
(State University of New York at Buffalo, 2018)
The September 11 attacks have been often referred to as an unprecedented historical event defining the twenty-first century. Live broadcasts of the event in real time have rendered 9/11 an unprecedented visual disaster ...