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Copper(II) facilitated aminofunctionalization of alkenes for the synthesis of nitrogen heterocycles
Several methods for the aminofunctionalization of alkenes have been developed that utilize copper(II) salts in either catalytic or stoichiometric amounts.
Diastereo- and enantioseletive copper(II)-catalyzed intramolecular carboamination of alkenes for the synthesis of benz[f]indoles and related heterocycles
The carboamination of alkenes is a well-studied method toward the synthesis of nitrogen heterocycles. This reaction involves the concurrent formation of C-N and C-C bonds across an olefin. Recent studies involving palladium ...
Structural characterization of JAA-F11-Fab by X-ray crystallography
Thomsen Friedenreich antigen (TF-Ag), is a carbohydrate antigen found on many types of tumors, including breast, prostate, bladder and ovarian. Passive transfer of JAA-F11, a monoclonal anti-TF-Ag antibody, has been shown ...
Hybrid polymer:inorganic-nanoparticle composite devices for photodetection and photovoltaics
Conjugated organic polymers and molecules exhibit semiconducting properties which are in many respects similar to those of traditional inorganic semiconductors that make them suitable for practical optoelectronic devices. ...
Effects of strain on phonon interactions and phase nucleation in several semiconductor and nano particle systems
Raman scattering is utilized to explore the effects of applied pressure and strain on anharmonic phonon interactions and nucleation of structural transitions in several bulk and nanoparticle semiconductor systems. The ...
Unconventional magnetism in bulk and nanostructured semiconductors
The goal of this thesis is to understand the unconventional magnetism (also known as sp/d 0 magnetism) exhibited by certain bulk and nano-structured semiconductors and insulators, that are not intentionally doped with ...
Copper(II) promoted and catalyzed difunctionalization of olefins: Carboamination and aminooxygenation efforts toward the synthesis of spirotryprostatin A
The development of copper(II) promoted and catalyzed difunctionalization reactions is discussed. These methods synthesize a variety of complex nitrogen heterocycles in enantioenriched form. Furthermore, attempts to apply ...
Role of the Escherichia coli beta-clamp, RecA activation and the SOS response in DNA polymerase selection
Error-prone DNA polymerases (pols) are conserved in all three kingdoms of life to promote the potentially mutagenic process of translesion DNA synthesis (TLS) following DNA damage. Due to their reduced fidelity, organisms ...
Understanding the Non-Ribosomal Peptide Synthetase (NRPS) system through structural and functional studies of the adenylate-forming family of enzymes
Non-Ribosomal Peptide Synthetases (NRPS) are large multi-domain enzymes that produce biologically important macromolecules. This includes peptide-derived antibiotics and siderophores that have high affinity for iron. These ...
Evaluation of flow with dynamic x-ray imaging for aneurysms
The main goal of this thesis is to evaluate blood flow inside cerebrovascular aneurysms using dynamic x-ray imaging. X-ray contrast substance (dye) was auto injected in elastomer aneurysm models placed in a flow loop (for ...