Now showing items 61-70 of 308
Copper(II) facilitated aminofunctionalization of alkenes for the synthesis of nitrogen heterocycles
Several methods for the aminofunctionalization of alkenes have been developed that utilize copper(II) salts in either catalytic or stoichiometric amounts.
Diastereo- and enantioseletive copper(II)-catalyzed intramolecular carboamination of alkenes for the synthesis of benz[f]indoles and related heterocycles
The carboamination of alkenes is a well-studied method toward the synthesis of nitrogen heterocycles. This reaction involves the concurrent formation of C-N and C-C bonds across an olefin. Recent studies involving palladium ...
A study of polymer tertiary structure in Langmuir monolayer films of poly(dimethyl siloxane) by time-of-flight secondary ion mass spectrometry, reflection-absorption Fourier transform infrared spectroscopy and high-resolution electron energy loss spectroscopy
The primary focus of this thesis is development of vibrational spectroscopy and the use of time of flight secondary ion mass spectrometry (ToF-SIMS) to identify surface tertiary structures of macromolecules. For this ...
Automated multi-parametric sorting of micron-sized particles via multi-trap laser tweezers
The capabilities of laser tweezers have rapidly expanded since the first demonstration by Ashkin and co-workers in 1970 of the ability to trap particles using optical energy. Laser tweezers have been used to measure ...
New generation chemical sensors and sensor systems
Chemical sensors have become a valuable method for the detection and quantification of a multitude of analytes. The ideal sensor and sensor system would be portable, inexpensive, readily fabricated, and monitor and quantify ...
Understanding the Non-Ribosomal Peptide Synthetase (NRPS) system through structural and functional studies of the adenylate-forming family of enzymes
Non-Ribosomal Peptide Synthetases (NRPS) are large multi-domain enzymes that produce biologically important macromolecules. This includes peptide-derived antibiotics and siderophores that have high affinity for iron. These ...
Time dependent density functional theory modeling of chiroptical properties of amino acids in solution
Time Dependent Density Functional Theory (TDDFT) and the COnductor-like Screening MOdel (COSMO) of solvation were used to model the specific rotation and Optical Rotatory Dispersion (ORD) of various amino acids in solution. ...
Evaluation of flow with dynamic x-ray imaging for aneurysms
The main goal of this thesis is to evaluate blood flow inside cerebrovascular aneurysms using dynamic x-ray imaging. X-ray contrast substance (dye) was auto injected in elastomer aneurysm models placed in a flow loop (for ...
Identification of sequential changes and investigation of change patterns in dynamic spatiotemporal data
Spatiotemporal data generally undergo fluctuations. Identifying a sequence of changes in spatiotemporal data and investigating patterns of the detected changes are commonly required across many domains for analysis, ...
Fundamental studies of the surface chemistry and photoinduced charge transfer reactivity of tethered semiconductor nanoassemblies
The focus of the research presented in this dissertation was two-fold: (1) the development of well-ordered assemblies of quantum dots (QDs) on surfaces through surfactant-mediated self-assembly; and (2) the study and ...