Now showing items 81-86 of 86
Dissection of the SSeCKS metastasis suppressor gene promoters: Identification of v-Src responsive elements
SSeCKS ( S rc- S uppressed C k inase S ubstrate), also called gravin/AKAP12, is a large scaffolding protein with metastasis suppressor activity. Two major isoforms of SSeCKS are expressed in most cell and tissue types under ...
Tumor vasculature as a therapeutic target for calcitriol in cancer
Calcitriol (1,25-dihydroxycholecalciferol), the active form of vitamin D is known to have anti-tumor activity both in vitro and in vivo in a wide variety of malignant cell types. Calcitriol is not only anti-proliferative ...
Role of the Escherichia coli beta-clamp, RecA activation and the SOS response in DNA polymerase selection
Error-prone DNA polymerases (pols) are conserved in all three kingdoms of life to promote the potentially mutagenic process of translesion DNA synthesis (TLS) following DNA damage. Due to their reduced fidelity, organisms ...
Computational fluid dynamic studies of endovascular stents for treating cerebral aneurysms
Endovascular stents provide a potentially viable treatment paradigm for cerebral aneurysms by modifying their hemodynamics. To understand how different endovascular stent designs and number of stents used can differentially ...
Increasing passive energy expenditure during clerical work
Standing rather than sitting for part of the workday may be a passive way to expend energy. Not all people may be motivated to stand while working so another possibility for increasing energy expenditure throughout the ...
Identification of a novel metabotropic glycine receptor and an excitatory pathway in retina
Glycine is a major inhibitory neurotransmitter in central nervous system that acts by opening a chloride channel. Ionotropic glycine receptors are blocked by strychnine, a potent competitive antagonist. Glycine receptors ...