Now showing items 81-86 of 86
Structural and functional characterization of the Hsp90 molecular chaperone family
Hsp90s are ATP-dependent molecular chaperones essential for the survival of all eukaryotic cells. They are among the most abundant proteins in the cell, consisting of over 2% of the total polypeptide mass and are key ...
Deuterium exchange studies and kinetics of Isopentenyldiphosphate Isomerase (IDI)
Isopentenyldiphosphate Isomerase (IDI) is a key enzyme in isoprenoid biosynthesis catalyzing the conversion of homoallylic isopentenyl pyrophosphate (IPP) to a more electrophilic dimethylallyl pyrophosphate (DMAP). The ...
A physics-based emulator for the simulation of geophysical mass flows
Rare natural hazards such as large volcanic eruptions can cause loss of life and damage to property. With sufficient information, those charged with public safety may issue warnings of impending hazards, to mitigate the ...
Prostate-specific antitumor effects of natural compounds: Isoliquiritigenin and alternol
Prostate cancer is the most commonly diagnosed form of cancer among men in the United States. It is second only to lung cancer as the leading cause of cancer-related deaths in males. The lethality of prostate cancer can ...
Chiroptical Properties of Transition Metal Complexes Investigated via Time Dependent Density Functional Theory
Chiroptical properties of several transition metal complexes have been investigated via the use of Time Dependent Density Functional Theory (TDDFT). The focus was on the Electric Circular Dichroism (ECD) and the Optical ...
Brønsted acid-promoted and Lewis acid catalyzed heterocyclization
Nitrogen and oxygen heterocycles occur in a wide variety of natural products and pharmaceuticals. Thus development of novel and efficient routes to six-membered nitrogen and oxygen heterocycles remains an essential area ...