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A study comparing the effects of continuous and cyclic oral contraceptive treatments on mammary gland microenvironment and tumor progression in BALB/c mice using the 4T1 transplantation model
Cyclic oral contraceptives (OC), although effective at preventing uterine and ovarian cancers, increase breast cancer risk. However, the effects of extended use (continuous) OC on breast cancer risk are unknown. We hypothesize ...
Elucidating chromosome territory organization during the cell cycle and in breast cancer cells
The interchromosomal spatial positionings of a subset of human chromosomes was examined in the human breast cell line MCF10A (10A) and its malignant counterpart MCF10CA1a (CA1a) and across the cell cycle in G1 and S phase ...
Breast epithelial morphogenesis: The role of annexins and primary cilia
Models of three dimensional (3D) mammary acinar morphogenesis are extensively used to study oncogenic transformation of breast epithelial cells. Using these models, factors and mechanisms that lead to aberrant 3D acinar ...
Effects of continuous and cyclic combined oral contraceptives on mouse mammary gland structure.
The breast goes through cycles of expansion, differentiation, and regression with every estrous/menstrual cycle, driven by hormonal stimulation followed by hormone withdrawal. The number of cycles over a lifetime is ...