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The role of Eph-ephrin signaling in antiangiogenic therapy-mediated resistance and metastasis
Resistance to antiangiogenic therapies in the treatment of metastatic renal cell carcinoma (RCC) remains a major clinical challenge. However, since the primary target of antiangiogenic therapy is the non-malignant vascular ...
FACT is an accelerator of tumorigenesis, a marker of aggressive, undifferentiated cancers, and a potential therapeutic target
Facilitates Chromatin Transcription (FACT) is a heterodimeric complex of subunits SSRP1 and Spt16 that is involved in chromatin remodeling during transcription, replication, and DNA repair. FACT was thought to be ubiquitously ...
A novel myosin and its role in metastatic prostate cancer
The majority of death from prostate cancer is caused by metastasis, the spreading of cancer cells from the primary tumors throughout the body. Yet, there is a distinct lack of understanding of the cellular factors and ...