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Investigating the serotonin 2C receptor as a candidate oncogene and drug target in advanced prostate cancer
Every year in the US, over 200,000 men are diagnosed with prostate cancer (PCa) and annual mortality in the US exceeds 30,000. PCa is treated surgically, and post-surgical recurrent tumors treated through targeted inhibition ...
Analysis of androgen receptor signaling and DNA methylation dynamics in prostate biology
DNA methylation is an epigenetic modification that contributes to stable gene silencing by interfering with the ability of transcriptional regulators to bind to DNA and, when found at high density, by recruiting ...
Role of PSA and interferon in prostate cancer gene expression and neovascularization
Prostate specific antigen (PSA) is a well-known biomarker utilized in the diagnosis and management of prostate cancer. PSA is a 33kDa member of the human tissue kallikrein family, exhibiting enzymatic-activity with ...
Effect of stress hormone on prostate cancer cells growth, migration, and invasion
In the United States, prostate cancer is the second most common cancer and the second leading cause of cancer death. Therefore, further understanding of this disease and the development for more therapeutic approaches is ...
Retinoic acid receptors and LSD1 as novel targets for prostate cancer
Castration resistant prostate cancer (CRPC) is the most aggressive and lethal form of prostate cancer (PCa) and novel therapies are required for its treatment. Epigenetic and genetic alterations are very common in CRPC ...