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A comparative study of photosensitizers with and without carbohydrate moieties
Many potentially useful photosensitizers for the photodynamic therapy (PDT) of malignancies have poor tumor selectivity. We hypothesized that certain carbohydrates on conjugating with photosensitizers at the optimal position ...
Yeast two-hybrid interaction partner screening through in vivo Cre-mediated binary interaction tag generation
Yeast two-hybrid (Y2H) is the tool of choice for the identification of novel protein-protein interactions, and it has been successfully used for genome-wide screens with several model organisms. Nonetheless, the logistics ...
Analysis of TGF-mediated dynamics in a system of many coupled nephrons
Previously, Pitman et al. (2002) derived an integral model of the tubuloglomerular feedback system. This integral model (also known as reduced model) describes the fluid flow up the thick ascending limb of a single, ...
Interactions between papillomavirus E1 and E2 proteins and cellular replication factors modulate each others functions
Along with the viral proteins E1 and E2, papillomavirus DNA replication is carried out by the cellular DNA replication machinery. Many of these cellular replication factors have been identified using a viral cell-free DNA ...
Analysis of the biosynthesis and function of a serotype B glycoform of Moraxella catarrhalis lipooligosaccharides
Moraxella catarrhalis is an important human pathogen and a major cause of otitis media in children and respiratory infection in adults with chronic obstructive pulmonary disease (COPD). Few virulence factors have been ...
Centrosomally localized EVI5 is a novel GTPase activator of the small GTPase Rab11 and may play crucial roles in cytokinesis and neuroblastoma development
Neuroblastoma is a disease that develops due to the failure of neural crest cells to migrate and differentiate properly. The human EV15 gene was isolated and characterized as a result of its location at the breakpoint ...