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Spatial genome organization: Interrelationships of chromosome territories and genes to nuclear architecture
The mammalian genome is housed in a membrane bound organelle referred to as the nucleus. The three dimensional structural organization of the nucleus has been implicated to affect various genomic functions. Each chromosome ...
Effects of chronic alcohol consumption and folate supplementation on the mouse mammary gland
Chronic alcohol consumption is a strong risk factor for breast cancer development in women. One potential mechanism linking alcohol and an increased risk of breast cancer development includes the ability for alcohol to ...
Structural characterization of JAA-F11-Fab by X-ray crystallography
Thomsen Friedenreich antigen (TF-Ag), is a carbohydrate antigen found on many types of tumors, including breast, prostate, bladder and ovarian. Passive transfer of JAA-F11, a monoclonal anti-TF-Ag antibody, has been shown ...
Microarray and real time-polymerase chain reaction analysis of mammary glands from rats fed conjugated linoleic acid
Conjugated linoleic acid (CLA) prevents mammary tumors in rats. The purpose of this study was to test the hypothesis that common pathways are altered by two similarly chemoprotective isomers, 9,11-CLA and 10,12-CLA. ...
Smad3 mediates TGF-beta induced apoptosis through the control of survivin expression in human breast cancer cells
Transforming growth factor-β (TGF-β) pathway initiates signaling by assembling receptor complexes that activate Smad transcription factors. TGF-β plays a key role in cell proliferation, differentiation and apoptosis. The ...
Immunohistochemistry of carcinomas using monoclonal antibody, JAA-F11
Thomsen Friedenreich antigen (TF-Ag) is a carbohydrate antigen that is exposed on various carcinomas including those of the breast, colon, bladder and prostate . The ubiquitous nature of this antigen indicates that it ...