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Characterizing regions associated with genomic instability in colon cancer
Most cancers can be considered to be the consequence of an unstable genome, where the instability can arise exogenously from carcinogens or endogenously from defects in systems that maintain genomic integrity. Genomic ...
Cell survival mechanisms associated with metastasis of human colon carcinoma
Colorectal cancer has the third highest incidence and is second highest in cancer-related death in the US. The majority of deaths are due to colorectal metastatic disease. Current treatment modalities are limited in their ...
Targeting EGFR and ErbB2 by small molecule tyrosine kinase inhibitors in human colon cancer
With the understanding of the molecular pathogenesis of colorectal cancer, novel molecular targeted therapies are being developed that may improve treatment of colorectal cancer. The identification of a causal role of ...
Evaluating sources of intrachromosomal instability in sporadic cancer genomes
Genomic instability is one of the hallmarks of tumorigenesis, although it is still disputed if this process acts as a progression facilitator, or is a secondary consequence of malignancy. Intrachromosomal genomic instability ...
Characterization of the genomic instabilities of sporadic colon cancer
Genomic instability is a hallmark of cancer and includes a range of alterations to the genome such as chromosomal alterations, intrachromosomal alterations and epigenetic alterations. Various forms of genomic instability ...