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Tandem cyclopropanation/ring closing metathesis, enyne metathesis: Developments and application towards natural product synthesis
Chapter one. Tandem cyclopropanation/ring-closing metathesis of dienynes . Certain dienynes give cyclorearrangement by tandem cyclopropanation/ring-closing alkene metathesis, triggered by either a ruthenium carbene or ...
The development of tandem reactions involving enyne metathesis to form substituted cyclic dienes
Enyne metathesis provides direct access to conjugated 1,3 dienes of varying substitution patterns under mild conditions. Our primary focus involves enyne metathesis catalyzed by the Grubbs-type carbene complexes. The ...
Ring synthesis by intermolecular methylene-free tandem enyne metathesis
Enyne metathesis provides an expedient atom-economical synthesis of 1,3-dienes. With the advent of functional group tolerant, highly active ruthenium-based catalyst systems, enyne metathesis has been applied to more and ...
Applications of enyne metathesis: Forming new methods and expanding scopes for use in natural product synthesis
Chapter 1. The biologically active epoxyquinoids are found to be inhibitors of cancer in tumor cell lines. In particular, the pentaketide dimer epoxyquinol A 1 , is known to inhibit angiogenesis (new blood vessel formation) ...
Kinetics and mechanism of intermolecular enyne metathesis
In chapter one of this dissertation the kinetics and mechanism of intermolecular enyne metathesis were investigated. Kinetic data were obtained using FT-IR spectroscopy by monitoring the terminal C-H stretching frequency ...
Enyne metathesis methods applied toward the total synthesis of natural products
Enyne metathesis is an extremely powerful method for the synthesis of conjugated 1,3-dienes that possess a variety of substitution patterns. This atom-economical transformation allows for complex functionality to be brought ...