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Increased plasma cell differentiation, hyper-responsiveness to TLR9, and loss of peripheral B cell tolerance in mice lacking the transcription factor Ets-1
(2007)
Systemic Lupus Erythematosus (SLE) is a polygenic disease influenced by abnormalities in genes, environmental factors and the immune system. One of the critical factors contributing to the pathogenesis of SLE is dysregulated ...
Vitamin C and collagen IV formation in fibroblasts
(2007)
Collagen IV (Col4) is a major component of vascular basement membranes (BM). Mice expressing mutated Col4 died shortly after birth with cerebral hemorrhage. Mice lacking the ubiquitous vitamin C (Asc) transporter SVCT2 ...
Fate and transport of persistent tetracycline residues in the environment
(2007)
Tetracycline antibiotics from human and veterinary use can enter the environment through the land-application of sewage sludge and/or animal manure that are used as soil conditioners. There has been an increased concern ...
Development of strategies to improve extraction, clean-up, and detection of tetracycline antibiotics from various soil types
(2007)
An optimized extraction and clean-up method for the analysis of tetracycline antibiotics in soil is presented in this dissertation. Soil extraction using different solvents was investigated, but the use of a 50/50 (v/v) ...
Determination of volatile organic compounds in biological fluids and tissues using solid phase microextraction and gas chromatography: Styrene and toluene
(2007)
Purpose. Epidemiological and animal research investigations have shown that toluene and styrene are toxic compounds that lead to impairment of the nervous system. Liquid-liquid phase, head-space and solid phase micro ...
Evaluation of flow with dynamic x-ray imaging for aneurysms
(2009)
The main goal of this thesis is to evaluate blood flow inside cerebrovascular aneurysms using dynamic x-ray imaging. X-ray contrast substance (dye) was auto injected in elastomer aneurysm models placed in a flow loop (for ...
Infrared spectroscopic analysis of restorative composite materials surfaces and their saline extracts
(2009)
Introduction . Tooth-colored resin fillings have become increasingly popular as restorative materials. This increase makes it important to differentiate among the materials for forensic and biological purposes. For the ...
Persistent organic pollutants (POPs) in the environment and their endocrine disrupting effects on fish
(2007)
Persistent organic pollutants (POPs) are chemical substances that have long half-lives in the environment, bioaccumulate through the food web, and may cause adverse health effects to humans and wildlife. Sediments from the ...
Structural characterization of JAA-F11-Fab by X-ray crystallography
(2007)
Thomsen Friedenreich antigen (TF-Ag), is a carbohydrate antigen found on many types of tumors, including breast, prostate, bladder and ovarian. Passive transfer of JAA-F11, a monoclonal anti-TF-Ag antibody, has been shown ...
The role of CARMA1 phosphorylation in T cell receptor-induced NF-kappaB activation
(2008)
The stimulation of T cell receptor (TCR) and CD3 complexes induces a series of signaling transduction events leading to activation of multiple transcription factors including NF-AT, NF-κB, and AP-1. The costimulation of ...