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Both FLT3-ITd and NPM1 mutations are associated with decreased MLLT3 mRNA expression in acute myeloid leukemia
BACKGROUND: Acute myeloid leukemia (AML) is a molecularly heterogeneous disease characterized by the accumulation of acquired somatic genetic alterations. The most clinically relevant gene mutations include internal tandem ...
Molecular mechanisms by which interferon regulatory factor-8 (IRF-8), a member of the IRF family of transcription factors, suppresses tumor progression of both hematopoietic and nonhematopoietic malignancies
It is well recognized that deregulation of certain transcription factors is indispensable during tumor progression. Identification and characterization of these genes are therefore fundamental requirements to inhibit the ...
Periodontal disease and cancer: Chronic inflammation - the oral-systemic link
Abstract removed at author's request.