Now showing items 1-6 of 6
HIF prolyl 4-hydroxylase (PHD) activity and the structure analysis: Blueprints for development of specific substrate inhibitors
The maintenance of oxygen homeostasis is a primary requirement that shapes the development, growth and internal organization for all multicellular species. When the delicate balance between oxygen supply and demand is ...
Quorum sensing in Pseudomonas aeruginosa: Design, synthesis and analysis of autoinducer analogs as antagonists for the quorum sensing pathway
Quorum sensing (QS) regulates production of virulence factors and maturation of biofilm in many bacteria, including Pseudomonas aeruginosa . The QS cascade is activated by the interaction of bacterial signaling molecules, ...
The iron response regulator: A bridge between heme biosynthesis and iron metabolism in Bradyrhizobium japonicum
Heme is an essential molecule involved in many cellular functions. The heme biosynthetic pathway is coordinated with iron availability and other variables to accommodate the cellular demand for heme. The iron response ...
Tumor immune escape: Molecular mechanisms and counteracting strategies
Changes in HLA class I antigen and NK cell-activating ligand expression have been identified in malignant lesions. These changes are believed to play a major role in the clinical course of the disease since both HLA class ...
X-ray region of interest imaging system for rapid-sequence angiography and fluoroscopy: The micro-angiographic fluoroscope
Neuro-endovascular interventional diagnosis and treatment require high resolution x-ray imaging guidance of fluoroscopy and angiography. Our group has developed a small field of view, 5 frames per second, high-resolution ...
RecA and repressor: Working together to save phage
The CI repressor protein of bacteriophage 434 is a transcriptional regulator of the life cycle of bacteriophage 434. 434 repressor directs transcription of its own gene while repressing transcription of genes that are ...