Now showing items 1-10 of 137
Development of Nano-Liposomal Formulations of Epidermal Growth Factor Receptor Inhibitors and their Pharmacological Interactions on Drug-Sensitive and Drug-Resistant Cancer Cell Lines
A rapidly expanding understanding of molecular derangements in cancer cell function has led to the development of selective, targeted chemotherapeutic agents. Growth factor signal transduction networks are frequently ...
An information theoretic framework for identification and modeling of gene-gene and gene-environment interactions
In this dissertation, we develop, extend, validate and apply information theoretic metrics for identification and characterization of interactions among genetic variations in the epidemiological studies as studies have ...
An examination of T-wave alternans as a predictor of sudden cardiac death in pigs
Sudden Cardiac Death (SCD), a death occurring due to abrupt loss of heart function is a leading cause of death in industrialized countries. As the event can occur unexpectedly without prior symptoms, it is has become a ...
Jnk-mediated regulation of adherens junctions and lentiviral infection
Cell-cell adhesion is dynamically regulated under different biological circumstances such as the establishment of epithelial cell polarity, wound healing, cell scattering and tumorigenesis. However, the mechanism of adherens ...
Developing computational and molecular tools to engineer the microbial biosynthesis of natural products
This dissertation represents an effort in the expanding field of metabolic engineering. Designing cellular phenotypes using metabolic engineering principles for the production of natural products is becoming an increasingly ...
Endothelial cell apoptosis in high wall shear stress and wall shear stress gradient environments
Vascular diseases like cerebral aneurysms and atherosclerosis are leading causes of mortality worldwide, and account for over 860,000 deaths annually in the United States. The vessel wall is an integrated organ composed ...
Blood proteins in aqueous solutions
The conformation of proteins in solution and on surfaces, as well as changes in the protein conformation caused by other molecules present in solution or external stimuli (e.g., temperature), are central to the biological ...
Blood flow measurement from digital angiography
Computational fluid dynamic (CFD) simulations are emerging as a promising tool for diagnosis and treatment planning of vascular diseases such as intracranial aneurysms. In addition to the three-dimensional luminal geometry, ...
Development and evaluation of a new high-sensitivity, region-of-interest, x-ray imaging system for neuro-interventional applications
Neurovascular image-guided interventional (IGI) procedures require very high resolution (3 to 10 lp/mm), large dynamic range, and real-time imaging capability for visualization and navigation of endovascular devices during ...
Robust microbial fabrication of plant pharmaceuticals: Complexities and solutions
Abstract not available.