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Mild hyperthermia influences macromolecular dynamics at the T cell surface thus increasing the efficiency of stimulatory signals
(2010)
There is growing recognition of the fact that although the effects of fever-range hyperthermia may be less extreme than that of heat shock temperatures, they may be more biologically significant. Our lab recently demonstrated ...
The role of subunit 9 in the structure, function and regulation of the Trypanosoma brucei ATP synthase
(2010)
The Trypanosoma brucei ATP synthase functions as a hydrolase in bloodstream form parasites and as a synthase in the procyclic form parasites. The dual functionality of the complex enables the parasite to maintain the ...
Gonadotropin stimulated apolipoprotein A-IV gene expression in human ovarian granulosa cells in vitro
(2010)
Background. There is increasing evidence that high density lipoprotein (HDL) metabolism is important to mammalian female fertility. HDL is the sole lipoprotein in human ovarian follicular fluid (FF) and FF-HDL levels have ...
Development of Nano-Liposomal Formulations of Epidermal Growth Factor Receptor Inhibitors and their Pharmacological Interactions on Drug-Sensitive and Drug-Resistant Cancer Cell Lines
(2010)
A rapidly expanding understanding of molecular derangements in cancer cell function has led to the development of selective, targeted chemotherapeutic agents. Growth factor signal transduction networks are frequently ...
Lubricating biologic surfaces with hydroxypropyl guar and hyaluronic acid
(2010)
Excellent in-the-eye lubricity has been reported for new ophthalmic products containing hydroxypropyl guar galactomannan (HPGG), comparable to that of standard hyaluronic acid (HA) preparations, but the mechanistic details ...
Anti-inflammatory cytokine IL-10 and mammary gland development
(2010)
Background . IL-10 is an anti-inflammatory cytokine produced by Th2 T helper cells and it has pleiotropic effects in immunoregulation and inflammation. It inhibits the regulation of Th1 T helper cells, MHC class II expression ...
Phenotypic changes in the variant of 4T1 cell line
(2010)
By targeting and preventing cancer metastasis, the lethality of the disease can be decreased so that it would be curable. The primary goal of this research was to further understand the metastatic process and understand ...
Development and evaluation of a new radiographic and fluoroscopic imager based on electron-multiplying CCDs: The solid state x-ray image intensifier
(2010)
A new dual detector system was developed which utilizes a low resolution, large field-of-view x-ray image intensifier (II) and a high resolution, region-of-interest microangiographic (MA) detector on the same c-arm gantry. ...
Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection
(2010)
Host immune responses, including the characteristic influx of neutrophils, against Neisseria gonorrhoeae are poorly understood; adaptive immunity is minimal and nonprotective. The importance of the newly defined Th17 cell ...
The oral microbiota and oral squamous cell carcinoma
(2010)
Background. The human oral cavity is populated by a complex microbiota, or oral microbiome, assembled from collection of over 800 bacterial phylotypes. While the majority of oral bacteria are commensals associated with ...