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Development of a framework to account for uncertainty sources in modeling toxic concentrations in the Niagara River
(2007)
The Niagara River is an important natural resource for drinking water and inexpensive hydroelectric power production. However, the quality of its water is less than pristine. Past lax management of toxic waste has left ...
Development of strategies to improve extraction, clean-up, and detection of tetracycline antibiotics from various soil types
(2007)
An optimized extraction and clean-up method for the analysis of tetracycline antibiotics in soil is presented in this dissertation. Soil extraction using different solvents was investigated, but the use of a 50/50 (v/v) ...
Terahertz spectroscopy of semiconductor nanostructures
(2007)
Electromagnetic waves centered at a frequency of 1 terahertz (THz) lie between the realms of photonics and electronics. Only recently have techniques been established to generate and detect electromagnetic waves in this ...
An alcohol dehydrogenase ribozyme: Evolution, characterization and reengineering
(2007)
I report a ribonucleic acid (RNA) molecule that exhibits activity analogous to that of alcohol dehydrogenase (ADH). Directed in vitro evolution was used to enrich nicotinamide adenine dinucleotide (NAD + )--dependent ...
The study and analysis of heterogeneity correction algorithms used in the delivery of step and shoot and sliding window IMRT
(2007)
The accuracy of tissue heterogeneity dose correction algorithms for IMRT delivery using step and shoot and sliding window techniques is studied. A solid water phantom incorporating a lung equivalent heterogeneity layer was ...
Study of the effect of tungsten shields on the radiation dose delivery in a gynecological applicator using Gafchromic film dosimetry
(2007)
Fletcher Suit Delclos applicator is employed for high dose rate intracavitary brachytherapy treatment of cervical cancer. It includes tungsten shields in the direction of bladder and rectum to limit their radiation exposure. ...
Persistent organic pollutants (POPs) in the environment and their endocrine disrupting effects on fish
(2007)
Persistent organic pollutants (POPs) are chemical substances that have long half-lives in the environment, bioaccumulate through the food web, and may cause adverse health effects to humans and wildlife. Sediments from the ...
Molecular mechanisms of conformational specificity: A study of Hox in vivo target DNA binding specificities and the structure of a Ure2p mutation that affects fibril formation rates
(2008)
The fate of an individual cell, or even an entire organism, is often determined by minute, yet very specific differences in the conformation of a single protein species. Very often, proteins take on alternate folds or even ...
Design and synthesis of carbocyclic nucleoside inhibitors for methylthioadenosine/S-adenosyl homocysteine nucleosidase
(2008)
The aim of this project was to synthesize carbocyclic inhibitors for methylthioadenosine/S-adenosyl homocysteine (MTA/SAH) nucleosidase. This enzyme is present only in microbes. The human analogue called MTA phosphorylase, ...
Aerosol spray pyrolysis & solution phase synthesis of nanostructures
(2008)
This dissertation focuses on the synthesis of nanomaterials by both solution phase and gas phase methods. By the solution phase method, we demonstrate the synthesis of Au/CdS binary hybrid nanoparticles and the Au-induced ...