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Engineering the acetylcholine receptor gating conformational change
Acetylcholine receptors (AChRs) are allosteric proteins that respond to acetylcholine (ACh) in the extracellular solution. These membrane proteins alternate spontaneously (`gate') between two global shapes, R and R*. R has ...
Modeling of dopamine-dependent disorders in a transgenic mouse and therapeutic targeting of dopamine circuits through nicotinic acetylcholine receptors
Schizophrenia and Parkinson's disease (PD) and related neurodevelopmental and neurodegenerative disorders are highly prevalent and extremely debilitating diseases. A common feature of these disorders is an impairment of ...