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Mechanism of anionic phospholipids mediated mitigation of immunogenicity of recombinant human factor VIII
The primary objective of this research work was to take a rational and stepwise approach to investigate the mechanism of phosphatidylserine/phosphatidylinositol (PS/PI) effect on reducing Factor VIII immunogenicity. The ...
FcRn-IgG Interaction: Development of FcRn Inhibitors and PBPK Modeling
The neonatal Fc receptor (FcRn) is known to play an essential role in extending IgG systemic persistence and in maintaining IgG homeostasis by protecting IgG from lysosomal catabolism. Inhibiting FcRn-IgG interaction with ...
Erythropoietin receptor pool dynamics: Its role in pharmacokinetics and pharmacodynamics of erythropoiesis-stimulating agents
The main aim of my Ph.D thesis is to advance the understanding of the concentration-effect relationship of erythropoiesis-stimulating agent (ESAs) with considering the role of the erythropoietin receptor pool dynamics on ...