Now showing items 1-10 of 40
The effect of operational parameters on the fate of tetracycline resistant bacteria in biological wastewater treatment plants
The main focus of this research is to study the fate of antibiotic resistant organisms in biological treatment processes as a function of operation and antibiotic presence. Data generated as a part of this study are expected ...
System-level modeling and analysis of biological reaction networks in signal transduction and glycosylation
Novel high-throughput genomic and proteomic tools are allowing the integration of information from a range of biological assays into a single conceptual framework. This framework is often described as a network of biochemical ...
Structure-property relationships in associating polymer solutions
Abstract not available.
A screw-theoretic framework for musculoskeletal system modeling and analysis
This thesis will address the development of tools for musculoskeletal system analysis, leveraging methodologies which have revolutionized the engineering domains. In particular, screw-theoretic modeling and analysis ...
Optimization and regulation of insulin expression from genetically modified skin cells
It has been shown that genetically modified keratinocytes (skin stem cells) can secrete proteins less than 16 kDa via the capillaries to the blood stream. Here we demonstrate that human epidermal keratinocytes can be ...
Endothelial cell layer subjected to flow mimicking the apex of an arterial bifurcation
Endothelial cell response to shear stress and shear stress gradients is widely accepted as a mediator of vascular pathology, including intracranial aneurysms. To this point, most in vitro research on endothelial cells ...
Metabolic engineering of Escherichia coli and Saccharomyces cerevisiae to mutasynthesize natural phenylpropanoids and novel analogs
The current dissertation investigated the biosynthesis of natural and unnatural flavonoids using Escherichia coli and Saccharomyces cerevisiae. Flavonoids are a diverse group of secondary metabolites found ubiquitously in ...
Use of fibrin hydrogels for localized and cell-controlled lentiviral gene delivery
Recombinant lentiviruses are efficient gene delivery vehicles with the ability to infect non-dividing cells including neurons, hematopoietic and embryonic stem cells. In addition to high efficiency several applications may ...
Computational fluid dynamic studies of endovascular stents for treating cerebral aneurysms
Endovascular stents provide a potentially viable treatment paradigm for cerebral aneurysms by modifying their hemodynamics. To understand how different endovascular stent designs and number of stents used can differentially ...
Functional module identification and function prediction from protein interaction networks
Since the completion of sequencing human genome, uncovering the principles of interactions and the functional roles of proteins has been in the spotlight in this post-genomic era. The interactions between proteins provide ...