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Hemodynamics induced intracranial aneurysm initiation: Mechanism and model exploration
Understanding the molecular mechanisms of intracranial aneurysms (IAs) is paramount to developing treatment strategies for preventing IA initiation and growth, and to understanding why some IAs are asymptomatic while others ...
Computer Modeling of Neurovascular Flow Diverter
Intracranial aneurysm rupture is one of the main contributors (15%) to subarachnoid stroke, which is identified as the third deadliest disease in North America. Among current widely used treatment strategies, flow diversion ...
Endothelial Cells under High Wall Shear Stress and Spatial Gradients
An intracranial aneurysm (IA) is a pathological bulging or dilation of a cerebral vessel which develop at apices of bifurcations or the outer sides of curved vessels. These locations represent a special hemodynamic environment ...
Correlating in-vivo hemodynamics with vascular responses
The roles of hemodynamics in the natural history of vascular diseases remain unclear due to a lack of understanding of the cellular and molecular responses under various hemodynamic stimuli. In vivo quantitative hemodynamics, ...
The Role of Smooth Muscle Cells in a Rabbit Model of Hemodynamic Intracranial Aneurysm Initiation
Intracranial aneurysm (IA) is a complex disease which causes sub arachnoid hemorrhage with devastating consequences. There are many risk factors for IA, but hemodynamic forces play a unique role. In order to better understand ...