Now showing items 1-10 of 14
Analysis of TGF-mediated dynamics in a system of many coupled nephrons
Previously, Pitman et al. (2002) derived an integral model of the tubuloglomerular feedback system. This integral model (also known as reduced model) describes the fluid flow up the thick ascending limb of a single, ...
Inter-domain regulation of Von Willebrand factor's function: Platelet adhesion, activation and aggregation in blood
Cardiovascular diseases are the primary cause of deaths worldwide and according to the World Health Organization; it is projected to cause the death of about 25 million people by 2030. Multiple factors cause the abnormalities ...
Mathematical Modeling of N-Glycosylation: Model Construction and Parameter Estimation from Mass Spectra of Chinese Hamster Ovary Cell Mutants
Colossal advances in molecular cellular biology have witnessed the growth of genomics, proteomics and other "–omics" fields, built on reductionist approaches aimed at annotating a vast array of biological components, from ...
R Packages for density based empirical likelihood based hypothesis tests
This thesis presents the functionality of two new R packages for performing goodness-of-fit tests based on density based empirical likelihood methods: dbEmpLikeGOF and dbEmpLikeNorm. The dbEmpLikeGOF function dbEmpLikeGOF ...
Metabolic engineering of Escherichia coli and Saccharomyces cerevisiae to mutasynthesize natural phenylpropanoids and novel analogs
The current dissertation investigated the biosynthesis of natural and unnatural flavonoids using Escherichia coli and Saccharomyces cerevisiae. Flavonoids are a diverse group of secondary metabolites found ubiquitously in ...
Mannosylated bio-synthetic hybrids for targeted antigen presenting cell gene delivery
The aim of gene delivery research is to develop clinically pertinent vectors that can be used to combat elusive diseases. Moreover, gene modulation efficacy of nonviral vectors have been hindered by numerous in vitro and ...
Matrigel and Mass Spectrometry
Matrigel is one of the most prolific 3-D growth cultures used for tumor invasion assays, tissue engineering and for stem cell growth. Produced from the Engelbreth-Holm-Swarm (EHS) tumor sarcoma cells of mice and containing ...
Robust microbial fabrication of plant pharmaceuticals: Complexities and solutions
Abstract not available.
Chemical and Biological Attenuation Methods for Bacterial Mediated Gene Delivery
The development of nonviral vectors for safe and effective gene delivery system is acquiring significant consideration at the present time. Ideally a nonviral vector must overcome the barrier of extracellular milieu, ...
Impairment in the Ubiquitin Proteasome System in hereditary peripheral neuropathies
In several neurodegenerative diseases in which misfolded proteins accumulate there is impairment of the ubiquitin proteasome system (UPS). We tested if a similar disruption of proteostasis occurs in hereditary peripheral ...