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Heme as an iron source and as a target for manganese-mediated regulation of iron metabolism in Bradyrhizobium japonicum
Iron is required for a wide variety of biological functions but can be a limiting nutrient in most bacterial niches. Many bacteria can utilize heme as an alternative source of nutritional iron. However heme degrading enzymes ...
The iron response regulator: A bridge between heme biosynthesis and iron metabolism in Bradyrhizobium japonicum
Heme is an essential molecule involved in many cellular functions. The heme biosynthetic pathway is coordinated with iron availability and other variables to accommodate the cellular demand for heme. The iron response ...
Differential control of Bradyrhizobium japonicum iron stimulon genes by the iron response regulator
Iron is an essential nutrient, but can be toxic at high concentrations as it can induce oxidative stress. Therefore, intracellular iron levels must be tightly regulated. The Irr protein in the bacterium Bradyrhizobium ...
Control of ferric iron acquisition and reduction by Irr in the bacterium Bradyrhizobium japonicum
Iron utilization by bacteria in aerobic environments involves uptake as a ferric chelate from the environment by ferric siderophore receptors, followed by reduction to the ferrous form. Ferric siderophore receptors are ...