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Prostate cancer chemoprevention and characterization of vitamin D insensitivity in prostate cancer
Prostate cancer (CaP) is one of the leading causes of cancer and cancer-related mortality in American men. The current standard treatments for early stage, organ-confined CaP includes surgery and radiation therapy. However, ...
Examination of the role of DNA methylation changes in prostate cancer using the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) model
The objectives of this dissertation are (1) to characterize DNA methyltransferase (Dnmt) expression and aberrant DNA methylation throughout TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) tumor progression; (2) to ...
The altered function and expression if iPLA2-beta in prostate tumor cells
Growth, development, and function of the prostate gland are regulated through the androgen receptor (AR), and prostate cancer is associated with aberrant regulation of the AR. Three isoforms of a recently discovered calcium ...