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Analysis of androgen receptor signaling and DNA methylation dynamics in prostate biology
DNA methylation is an epigenetic modification that contributes to stable gene silencing by interfering with the ability of transcriptional regulators to bind to DNA and, when found at high density, by recruiting ...
Examination of the role of DNA methylation changes in prostate cancer using the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) model
The objectives of this dissertation are (1) to characterize DNA methyltransferase (Dnmt) expression and aberrant DNA methylation throughout TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) tumor progression; (2) to ...