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Down regulation of RARγ in Prostate Cancer and the Potential control of its Expression via microRNA-96
Background: Knockout of Rarγ leads to prostate neoplasia. Similarly stem cell research has identified RARγ as the main nuclear receptor for ATRA signaling. Although the RARγ is eminently druggable, clinical trials have ...
The roles of the E26 transcription family member, SAM pointed domain-containing ETS transcription factor (SPDEF), in early stage prostate cancer and the development of castration recurrent disease
One of the greatest problems in prostate cancer management today is accurate identification of patients who require treatment for aggressive disease versus those with indolent disease who are suitable for observational ...