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Assessing PDT response with diffuse optical spectroscopies
(2015)
Photodynamic therapy (PDT) is used to treat a variety of conditions including cancer. Effective PDT requires three components: a photosensitizer (PS), light of a specific wavelength to activate the PS and oxygen. When all ...
Split-dose photodynamic therapy: Optimizing cures while preventing disseminated tumors
(2012)
Photodynamic therapy (PDT) is an FDA approved treatment for a number of malignant and non-malignant conditions in humans. Previous pre-clinical work in murine tumor models has shown that low-inflammation ( high-fluence ) ...
Delmopinol-induced matrix removal facilitates photodynamic therapy and chlorhexidine methods for disinfecting mixed oral biofilms
(2014)
It is often observed that the slimy matrixes of various bacterial-formed biofilms can limit their disinfection. This investigation demonstrated that disinfection effectiveness by either photodynamic therapy (PDT) or ...
Comparative evaluation of two different diode laser wavelengths with and without photosensitization for suppressing bacterial colonization on dental implants surfaces. Ex-vivo study
(2015)
Background: Peri-implant disease is now an important topic in the dental implant literature. Therapeutic use of the the diode laser has shown promising results in management of peri-imlantitis. Photodynamic therapy (PDT) ...
Tumor imaging and photodynamic therapy (PDT) using versatile chlorin near infrared fluorophore (NIRF) conjugates
(2013)
Near-infrared (NIR) organic dyes have become important for many biomedical applications, including in vivo optical imaging. Conjugation of NIR fluorescent dyes to photosensitizing molecules (photosensitizers) holds strong ...
The mechanisms of photodynamic therapy induced anti-tumor immunity
(2013)
Photodynamic therapy (PDT) has long been shown to be capable of killing malignant cells, causing shut down of tumor microvasculature, and induction of host immune response. The therapeutic efficacy of PDT is dependent on ...
Optimization of tumor-imaging and therapeutic potential of near-infrared multifunctional agents, and targeted polyacrylamide theranostic nanoplatforms
(2016)
The goal of this work was to modify the structural parameters of porphyrin-based agents to optimize their imaging and/or therapeutic potential. In order to achieve our goal, certain chlorins and bacteriochlorins were ...