Now showing items 1201-1206 of 1206
Lipid-based strategies to overcome pharmacokinetic and immunogenicity issues of therapy with recombinant human acid alpha-glucosidase
Acid α-glucosidase (GAA) is the sole enzyme capable of catalyzing the breakdown of glycogen stored within the lysosomes of the cells throughout the body into glucose. Dysfunction or complete deficiency of GAA leads to a ...
Awareness Of Medication-Related Osteonecrosis Of The Jaw (MRONJ) Among Oncology Dental Patients With Risk Factors For MRONJ
Introduction: Medication related osteonecrosis of the jaw (MRONJ) is exposed bone in the maxillofacial region that does not heal within eight weeks after identification by a health professional. Cancer patients taking or ...
Meaningful Wandering for Residents with Alzheimer's Disease in Memory Care Facilities
Background: For individuals with Alzheimer’s disease, the built environment can be a powerful therapeutic tool. Existing research shows that helpful environmental conditions can 1) ease negative behaviors associated with ...
Association between subgingival bacteria and metabolic syndrome among postmenopausal women in Buffalo OsteoPerio study
Background: According to national surveillance data, the prevalence of both metabolic syndrome and clinically measured periodontal diseases is high in the overall U.S. population of adults and increases with age. No published ...
Polarized trafficking of multipass membrane proteins in Madin-Darby canine kidney cells likely has limited sorting routes
Sodium-dependent vitamin C transporters, SVCT1 and SVCT2, are multi-pass membrane proteins sorted to the apical and basolateral membranes in epithelial cells, respectively. Sorting uses N- and C-terminal sequences. Previous ...
Wound healing efficacy of a class of antibacterial compounds
Two compounds namely PKZ1800 and PKZ1822, showing antibacterial activity were assessed for cytotoxic effects on WI38 fetal lung fibroblast cells. PKZ1800 showed potential toxic effects at a concentration of 80μg/ml. ...