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dc.contributorNot Applicableen_US
dc.contributor.authorDANIELS, DEREK Principal Investigatoren_US
dc.date30-Jun-14en_US
dc.date2010en_US
dc.date.accessioned2011-04-18T21:04:55Zen_US
dc.date.accessioned2011-04-19T18:31:19Z
dc.date.available1-Sep-09en_US
dc.date.available2011-04-18T21:04:55Zen_US
dc.date.available2011-04-19T18:31:19Z
dc.date.issued2011-04-18T21:04:55Zen_US
dc.identifier7905998en_US
dc.identifier5R01HL091911-02en_US
dc.identifier91911en_US
dc.identifier.urihttp://hdl.handle.net/10477/1084
dc.descriptionAddress;Adrenal Glands;Affect;analog;Angiotensin II;Angiotensin II Receptor;Angiotensins;Animals;base;Behavior;Behavioral;Behavioral Mechanisms;Binding (Molecular Function);Biochemical;Body Fluids;body system;Brain;Cardiovascular system;Cell Culture Techniques;citrate carrier;combat;Complement;desensitization;design;Diabetes Mellitus;Disease;Electrophysiology (science);Family member;Food;G-Protein-Coupled Receptors;Gastrointestinal tract structure;Health;Heart Diseases;Homeostasis;Hormones;Hypertension;Hypovolemia;Immunohistochemistry;Individual;Ingestion;inhibitor/antagonist;Inositol;insight;Intake;Intervention;Kidney;Lead;Left;Ligands;Liquid substance;Maintenance;Mediating;Mitogen-Activated Protein Kinase Inhibitor;Mitogen-Activated Protein Kinases;Mitogens;Molecular;Monitor;Muscle, Smooth, Vascular;neurochemistry;neuromechanism;novel therapeutic intervention;Obesity;Pathway interactions;Peptides;Phosphorylation;Physiological;Play;Protein Kinase C;Proteins;public health relevance;receptor;Receptor Activation;receptor coupling;receptor function;Receptor Signaling;Receptor, Angiotensin, Type 1;relating to nervous system;Relative (related person);Renin-Angiotensin System;research study;response;Role;salt intake;Signal Pathway;Signal Transduction;Site;System;Techniques;Testing;tool;Water;en_US
dc.descriptionAmount: $ 388331en_US
dc.description.abstractDESCRIPTION (provided by applicant): Maintaining cardiovascular health relies on a number of physiological and behavioral mechanisms that monitor, respond to, and alleviate perturbations in body fluid homeostasis. Angiotensin II (AngII), the bioactive product of the renin-angiotensin system, is an important component of these actions, especially in the response to hypovolemia. AngII affects numerous systems including the kidney, adrenal gland, gastrointestinal tract, vascular smooth muscle, and brain. The central effects of AngII include increases in water and NaCl intake, critical behaviors for the maintenance of body fluid and cardiovascular homeostasis. These behavioral effects are mediated largely through AngII type 1 (AT1) receptors, which stimulate several intracellular signaling pathways including one that leads to increased inositol trisphosphate (IP3) formation and protein kinase C (PKC) activation, and another that increases phosphorylation of mitogen activated protein (MAP) kinase. Recent experiments suggest different relative contributions of these pathways to the water and NaCl intake induced by AngII. The experiments in the present proposal use behavioral, pharmacological, electrophysiological, molecular, and neuroanatomical approaches to explore the role of these intracellular signaling pathways in the control of AngII- induced water and NaCl. Specifically, the experiments will (1) determine the roles of the Gq/IP3/PKC and MAP kinase signaling pathways in AngII-induced water and NaCl intake; (2) determine the role of individual signaling pathways on neural activity at primary and downstream sites of AngII action in the brain; and (3) test the role of these signaling pathways and receptor phosphorylation on desensitization of the intracellular and behavioral responses after multiple treatments with AngII. These experiments use a multifaceted approach and a variety of techniques to answer these questions from behavioral, anatomical, electrophysiological, and neurochemical perspectives. PUBLIC HEALTH RELEVANCE: Ingestion of water, salt, and food is critical for proper function of numerous body systems. Disorders related to energy and fluid imbalance include hypertension, obesity, heart disease, and diabetes. Understanding the neural mechanisms through which hormones mediate the ingestion of water, salt, and food may lead to novel therapeutic approaches to combat these relevant disease states.en_US
dc.titleROLE OF ANGIOTENSIN II RECEPTOR SIGNALING PATHWAYS IN BODY FLUID HOMEOSTASISen_US
dc.typeNIH Grant Awarden_US


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