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dc.contributorDr. Susan F. Volman Program Manageren_US
dc.contributor.authorStanley Halvorsen Principal Investigatoren_US
dc.datestart 07/15/1992en_US
dc.dateexpiration 06/30/1997en_US
dc.date.accessioned2014-04-02T18:16:07Z
dc.date.available2014-04-02T18:16:07Z
dc.date.issued2014-04-02
dc.identifier9210348en_US
dc.identifier.urihttp://hdl.handle.net/10477/22352
dc.descriptionGrant Amount: $ 212736en_US
dc.description.abstractCiliary neurotrophic factor, CNTF, is a protein known to promote survival and differentiation of specific classes of neurons grown in culture, as well as to affect the development of glial cells. The basic molecular mechanisms for the effects of CNTF are not known. A simple, easily accessible system, human neuroblastoma tumor cells, will be used to identify CNTF receptors. In addition, a pharmacological approach will be taken to characterize the intracellular mechanisms involved in transducing the CNTF signal to affect cell physiology. The regulation of CNTF receptors by neurotransmitters and ion channel ligands, as well as during phorbol ester induced cell differentiation will also be studied. These studies promise to provide fundamental knowledge about factors crucial to the development, survival, regeneration and aging of specific types of cells in the nervous system.en_US
dc.titleCiliary Neurotrophic Factor Receptors on Neuroblastoma Cellsen_US
dc.typeNSF Granten_US


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