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Development of Nano-Liposomal Formulations of Epidermal Growth Factor Receptor Inhibitors and their Pharmacological Interactions on Drug-Sensitive and Drug-Resistant Cancer Cell Lines
(2010)
A rapidly expanding understanding of molecular derangements in cancer cell function has led to the development of selective, targeted chemotherapeutic agents. Growth factor signal transduction networks are frequently ...
Both FLT3-ITd and NPM1 mutations are associated with decreased MLLT3 mRNA expression in acute myeloid leukemia
(2014)
BACKGROUND: Acute myeloid leukemia (AML) is a molecularly heterogeneous disease characterized by the accumulation of acquired somatic genetic alterations. The most clinically relevant gene mutations include internal tandem ...
Tumor vasculature as a therapeutic target for calcitriol in cancer
(2007)
Calcitriol (1,25-dihydroxycholecalciferol), the active form of vitamin D is known to have anti-tumor activity both in vitro and in vivo in a wide variety of malignant cell types. Calcitriol is not only anti-proliferative ...
P53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of tandem and interspersed repeats
(2012)
Inactivation or loss of p53 is associated with increased cell sensitivity to the DNA demethylating agent 5-aza-2'-deoxycytidine (5-aza-dC). To identify the factors that trigger apoptotic response under these conditions, ...
Glycan Signature Changes in Stem Cell Differentiation and Cancer
(2012)
Glycosyltransferase (glycoT) enzymes mediate the transfer of monosaccharide from nucleotide-sugars to carbohydrate, lipid and protein based acceptors leading to formation of glycans. The regulation of the glycan structures ...
The Role of Mitochondria in Alveolar Rhabdomyosarcoma
(2017)
Rhabdomyosarcoma (RMS) is the third most common type of solid tumors in children. The two main subtypes of RMS widely studied are embryonal RMS (eRMS) and alveolar RMS (aRMS). aRMS is characterized to have a more aggressive ...
Reduced glucose signaling and downregulation of survivin as potential anticancer therapeutic strategies
(2011)
The avid acquisition of glucose is a basic characteristic of cancer cells. This property is exploited to detect cancer and to monitor therapeutic response by employing glucose tracers in positron emission tomography (PET) ...
Dendritic cell-based approaches for the immunotherapy of malignant diseases
(2006)
The overall goal of this thesis is to develop and evaluate the immunogenicity and therapeutic efficacy of several interrelated strategies for the active specific immunotherapy of malignant diseases. The primary focal point ...
Improving the efficacy and selectivity of photodynamic therapy (PDT): Preclinical evaluation of a novel combination strategy for cancer
(2006)
Clinical application of photodynamic therapy (PDT) is limited by treatment failures that lead to tumor recurrences in patients. Based on previous observations that administration of tumor necrosis factor-alpha (TNF-α) ...
Regulation of hormone responsive cancers by Ca 2+ /calmodulindependent protein kinase kinase 2
(2013)
Steroid Receptors (SR) are oncogenic drivers of proliferation in hormonally regulated cancers. Immunohistochemistry (IHC) studies have shown high expression levels of Ca2+/calmodulin-dependent kinase kinase 2 (CaMKK2), an ...