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Computational tools for investigating the role of chromatin in regulating genomic functional elements
Chromatin is the nucleoprotein complex composed of histone protein and DNA found in the nucleus of every eukaryotic cell. The basic subunit of chromatin is the nucleosome, consisting of 147bp of DNA wrapped around a histone ...
Resolving genome-wide views of chromatin structure to identify fundamental principles of genome organization
Chromatin, the collection of DNA and proteins found in eukaryotic nuclei, is organized into a distinct structure to facilitate the compaction of genomic DNA. Chromatin structure is highly conserved across eukaryotic species ...
Determining the mechanistics of chromatin regulated p63 targeting using next-generation sequencing methods
Transcriptional regulation is a process that through complex interplay between cis-regulatory regions, trans-acting factors, chromatin features and higher-order genome organization leads to the implementation of lineage-specific ...
The response of proteasome activator 200kD to DNA damage
Upon exposure to DNA damaging agents, eukaryotic cells employ a complex cellular response, which includes cell signaling and protein recruitment events, in order to sense and repair DNA damage. The correction of DNA ...