Now showing items 1-10 of 16
Robust microbial fabrication of plant pharmaceuticals: Complexities and solutions
Abstract not available.
Molecular mechanisms regulating DeltaNp63 expression and function during development and differentiation of mouse skin keratinocytes
The skin is a multilayered stratified epithelium providing a protective barrier against dehydration and pathogenic insult. The transcription factor p63 plays an important role in the development of stratified epithelium ...
Vitamin C and collagen IV formation in fibroblasts
Collagen IV (Col4) is a major component of vascular basement membranes (BM). Mice expressing mutated Col4 died shortly after birth with cerebral hemorrhage. Mice lacking the ubiquitous vitamin C (Asc) transporter SVCT2 ...
Studies of structure, hydration and dynamics of biological macromolecules by use of NMR spectroscopy
Nuclear magnetic resonance (NMR) has emerged as a powerful tool for studying biological macromolecules in aqueous solution. This dissertation describes the efforts to study the structure, hydration and dynamics of biological ...
Heme-dependent regulation of bacterial cytochromes
The heme prosthetic group of heme proteins contains iron, which can be a limiting nutrient. In the current study, we found that expression of B. japonicum cytochrome c 1 , a subunit of the cytochrome bc 1 complex, is ...
The role of protein methylation in growth of Saccharomyces cerevisiae and a disruption mutant of SAH1
Growth of a disruption mutant of S-adenosylhomocysteine hydrolase (Δ SAH1) in S.cerevisiae is severely defective. A prolonged lag precedes log growth, the rate of log growth is 6.7-fold less than WT, and the number of cells ...
Developing site selectively templated and tagged xerogels as sensor platforms
Biologically-based recognition elements (e.g., antibodies, aptamers, enzymes) are used as the recognition element within a wide variety of assays and sensor systems. There are, however, compelling reasons for researchers ...
Molecular interactions between sodium channels and a novel neurotoxin, ProTx-II: Implications for the structure and function of voltage-gated sodium channels
Spider venoms are a rich source of highly specific peptide ligands that bind to voltage-gated calcium, potassium and sodium channels. These toxins have been used to help elucidate the structure and physiological roles of ...
Structure-function analysis of the Saccharomyces cerevisiae RNA polymerase II active center: A functional role for the switch 2 region in transcription start site utilization and abortive initiation
RNA polymerase II (RNAPII) is responsible for the synthesis of mRNA from eukaryotic protein-encoding genes. In this study, site-directed mutagenesis was employed to probe the function of residues within the Saccharomyces ...
The role of DNA replication in mismatch repair
DNA Mismatch Repair (MMR) plays an important role in maintaining genomic fidelity and stability in all living organisms, ranging from bacteria to humans, and is known to be closely associated with DNA replication and present ...