Now showing items 41-50 of 86
Robust microbial fabrication of plant pharmaceuticals: Complexities and solutions
Abstract not available.
Polymorphisms in the glutathione s-transferase genes and treatment outcomes in acute myeloid leukemia
Concordance between germline and tumor DNA samples were investigated to determine the feasibility of using stored tumor samples as a source of genomic DNA for acute myeloid leukemia (AML) pharmacogenetic studies. We compared ...
Phosphatidylserine mediated enhancement of the therapeutic efficacy of B domain deleted recombinant factor VIII
Factor VIII (FVIII) is an important cofactor in the blood coagulation cascade. Deficiency or dysfunction of FVIII causes hemophilia A, a life threatening bleeding disorder. Replacement therapy using FVIII is the first line ...
TbDSS-1 functions in mitochondrial RNA turnover and surveillance in Trypanosoma brucei
The parasitic protozoan Trypanosoma brucei is the causative agent of African sleeping sickness and nagana in wildlife and livestock. T. brucei is a member of the Order Kinetoplastida, so termed because of the unusual ...
Genetically altered expression of polyamine acetylation affects fat metabolism and body fat accumulation in mice
The polyamine acetylating enzyme, spermidine/spermine N 1 -acetyltransferase (SSAT), catalyzes the transfer of acetyl groups from acetyl-coenzyme A (acetyl-CoA) onto intracellular polyamines thereby rendering them susceptible ...
Characterizing regions associated with genomic instability in colon cancer
Most cancers can be considered to be the consequence of an unstable genome, where the instability can arise exogenously from carcinogens or endogenously from defects in systems that maintain genomic integrity. Genomic ...
Spatio-temporal landscape models for West Nile virus vector population abundance and distribution
In response to the rapid spread of West Nile virus throughout North America there has been an increase in the number of mosquito vector surveillance and control programs. However, mosquito surveillance programs are costly ...
Cadmium and mercury suppress cytokine receptor-mediated Jak/STAT activation by inhibiting mitochondrial function and increasing intracellular oxidative stress
The Janus kinase (Jak)/signal transducer and activator of transcription (STAT) pathway is an intercellular signal transduction mechanism that acts in many cell types, including neurons, during development and repair after ...
Molecular mechanism of inhibitor of kappa B kinase (IKK) complex activation by inducible phosphorylation and ubiquitination upon T cell receptor (TCR) stimulation
IκB kinase (IKK) complex serves as the master regulator for the activation of NF-κB by various stimuli. It contains two catalytic subunits, IKKα and IKKβ, and a regulatory subunit, IKKγ/NEMO. The activation of IKK complex ...
Phylogenetics and morphological evolution of Scleractinian corals
Scleractinian corals are modular organisms of great ecological and economic importance that may have solitary or colonial growth forms. In spite of the rich fossil record, the evolutionary history of the group is poorly ...