According to the Center for Disease Control and Prevention (CDC) about 65% of Americans are overweight or obese. Even though many factors such as genetic predisposition, sedentary lifestyle, and consumption of high caloric ...

The varicella zoster virus (VZV) ORF9 protein is a member of the herpesvirus UL49 gene family but shares limited identity and similarity with the UL49 prototype, HSV-1 VP22. ORF9 mRNA is the most abundantly expressed message ...

Endothelial cell response to shear stress and shear stress gradients is widely accepted as a mediator of vascular pathology, including intracranial aneurysms. To this point, most in vitro research on endothelial cells ...

Nuclear magnetic resonance (NMR) has emerged as a powerful tool for studying biological macromolecules in aqueous solution. This dissertation describes the efforts to study the structure, hydration and dynamics of biological ...

Stimulation of cells by TNFα triggers recruitment of various signaling molecules, including RIP, to the TNFα receptor 1 complex, which leads to activation of NF-κB. Previous studies indicate that RIP plays an essential ...

Stromal cells represent a novel target for chemopreventively modifying the breast microenvironment. The purpose of these studies was to test the hypothesis that conjugated linoleic acid (CLA) acts chemoprotectively against ...

Despite recent advances in therapy, acquired resistance is common among patients with B-cell non-Hodgkin's lymphoma (B-NHL). Targeting malignant B-cells using the anti-CD20 monoclonal antibody rituximab has improved the ...

Inflammation is mediated by many factors, principle among them pro-inflammatory cytokines. While inflammation is critical for host defense and resolution of infection, it is often pathologic in its unregulated state. ...

The mechanism by which T lymphocytes become activated during an immune response is complex. One important component of T lymphocyte activation is the CARMA1 protein, which plays an essential role in T cell receptor/CD28 ...

Glycine is a major inhibitory neurotransmitter in central nervous system that acts by opening a chloride channel. Ionotropic glycine receptors are blocked by strychnine, a potent competitive antagonist. Glycine receptors ...