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Tumor vasculature as a therapeutic target for calcitriol in cancer
(2007)
Calcitriol (1,25-dihydroxycholecalciferol), the active form of vitamin D is known to have anti-tumor activity both in vitro and in vivo in a wide variety of malignant cell types. Calcitriol is not only anti-proliferative ...
Characterization of pentatricopeptide repeat (PPR) proteins in Trypanosoma brucei
(2007)
Pentatricopeptide repeat proteins (PPRs) are one of the largest newly identified protein families. PPR is characterized by the presence of a tandemly repeated 35 amino acids motif. It is extremely abundant in plants, and ...
Functional architecture of the mammalian cell nucleus: An analysis of proximity relationships between genomic functions
(2007)
The results of simultaneous replication (RS) and transcription site (TS) labeling in HeLa cells not only revealed that these fundamental genomic processes exist in two spatially separate domains or zones, but also raised ...
Dissection of the SSeCKS metastasis suppressor gene promoters: Identification of v-Src responsive elements
(2007)
SSeCKS ( S rc- S uppressed C k inase S ubstrate), also called gravin/AKAP12, is a large scaffolding protein with metastasis suppressor activity. Two major isoforms of SSeCKS are expressed in most cell and tissue types under ...
Role of the Escherichia coli beta-clamp, RecA activation and the SOS response in DNA polymerase selection
(2007)
Error-prone DNA polymerases (pols) are conserved in all three kingdoms of life to promote the potentially mutagenic process of translesion DNA synthesis (TLS) following DNA damage. Due to their reduced fidelity, organisms ...
Computational fluid dynamic studies of endovascular stents for treating cerebral aneurysms
(2007)
Endovascular stents provide a potentially viable treatment paradigm for cerebral aneurysms by modifying their hemodynamics. To understand how different endovascular stent designs and number of stents used can differentially ...
Increasing passive energy expenditure during clerical work
(2007)
Standing rather than sitting for part of the workday may be a passive way to expend energy. Not all people may be motivated to stand while working so another possibility for increasing energy expenditure throughout the ...
The effect of platelet-rich plasma on primary human alveolar bone cells
(2007)
Platelet-rich plasma (PRP) is a source of growth factors that can promote surgical healing. It has been shown to increase the viability and proliferation of osteosarcoma cells (Kanno et al., 2005) and immortalized cell ...
Environmental and binding dependence of protein terahertz dielectric response
(2007)
Terahertz (THz) generation and detection techniques have been developed widely and improved in the last few decades. THz techniques have been applied to many fields, such as medical support (THz imaging for breast cancer ...
The response of proteasome activator 200kD to DNA damage
(2007)
Upon exposure to DNA damaging agents, eukaryotic cells employ a complex cellular response, which includes cell signaling and protein recruitment events, in order to sense and repair DNA damage. The correction of DNA ...