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Molecular mechanism of inhibitor of kappa B kinase (IKK) complex activation by inducible phosphorylation and ubiquitination upon T cell receptor (TCR) stimulation
(2007)
IκB kinase (IKK) complex serves as the master regulator for the activation of NF-κB by various stimuli. It contains two catalytic subunits, IKKα and IKKβ, and a regulatory subunit, IKKγ/NEMO. The activation of IKK complex ...
The role of RIP ubiquitination in the TNFalpha signaling pathway
(2007)
Stimulation of cells by TNFα triggers recruitment of various signaling molecules, including RIP, to the TNFα receptor 1 complex, which leads to activation of NF-κB. Previous studies indicate that RIP plays an essential ...
Analysis and characterization of CARMA1 interacting proteins
(2007)
The mechanism by which T lymphocytes become activated during an immune response is complex. One important component of T lymphocyte activation is the CARMA1 protein, which plays an essential role in T cell receptor/CD28 ...