Dietary factors and endometrial cancer
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Although reproductive and hormonal factors and obesity have been consistently associated with endometrial cancer, evidence regarding the role of dietary factors in its etiology has been limited. We examined the association between intakes of selected food groups and nutrients with endometrial cancer risk in a hospital-based case-control study. Statistically significant negative associations were observed for women in the highest vs. lowest quartiles of intake of total vegetables, vitamin E, dietary fiber, beta carotene, lutein, and folate. Statistically significant positive trends with intakes of animal fat, saturated fat, and animal protein as well as inverse associations with vegetable protein, alpha-carotene, vitamin C, and carbohydrates were found. Stratified analyses revealed inverse associations between vitamins C and E, alpha carotene, beta carotene, folate, and lutein among women who are not overweight or obese. Therefore, intake of animal foods may increase risk of endometrial cancer, while plant foods and carotenoids may decrease risk.