An emulsion of dodecafluoropentane (DDFPe) sustained oxygen delivery in spontaneously breathing swine after hemorrhagic shock
Johnson, Joshua Gale
MetadataShow full item record
Twelve spontaneously air breathing anesthetized male swine had a 48.7 ± 0.55 (s.e.) % reduction of their circulating blood volume through a controlled hemorrhage. The large decrease in the swines' circulating blood volume resulted in an acute circulatory dysfunction, where tissue perfusion was unable to sustain oxygen delivery and aerobic metabolism. Loss of oxygen delivery can ultimately lead to cell death, multi-organ tissue failure and death if untreated. An intravenously infused 0.5 ± 0.02 (s.e.) ml/kg of a 2% emulsion of dodecafluoropentane (DDFPe) reduced the effects of hemorrhagic shock. The DDFPe increased global oxygen delivery to the tissues by increasing the oxygen carrying capacity of the blood with the use of subcapilarry sized microbubbles. The mean survival of the group given the placebo was 185.7 ± 37.6 (s.e.) min while 100% of the animals given DDFPe survived past 440 ± 0.0 (s.e.) min. The results indicate that hypoxia is essential in the development of hemorrhagic shock and that a treatment of DDFPe may significantly increase survival time and reduce the effects a severe blood loss.