Comparison of cell proliferation and maturation of osteoblastic cells from a cancer patient treated with bisphosphonates and control osteoblastic cells on four different biomaterials
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The hypothesis of this study is that osteoblastic cells from cancer patients under bisphosphonates treatment may interact differently with potential reconstructive biomaterials and show enhanced cell activity, proliferation, and phenotype expression compared to osteoblastic cells from noncancerous patients. The results suggested that osteoblastic cells from the maxillary bone of cancer patients treated with bisphosphonates could show different cell activity and differentiation characteristics on titanium alloy, zirconium alloy, and stainless steel compared to normal maxillary bone osteoblastic cells. Higher cell activity on specific materials may be important for application of biomaterials in reconstructive surgery.