Candida albicans stress response mechanism
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Candida albicans is the predominant species of yeast isolated from patients with oral candidiasis, a manifestation of lowered host defenses. Under normal host immune response, Candida has to face a number of adverse conditions in order to survive. C. albicans Ssa1/2p, known members of the heat shock protein family, are better suited for stress protection because of their cell surface localization. However, analyses of Candida responses to oxidative, nitrosative and starvation stresses ruled out the possible role of ssa1/2p in direct protection from these stress conditions. Osmotic stress response was found to be initiated by Candida after treatment with Hst 5 as a stress factor. These stress responses provide insight into potential mechanisms employed by Candida to evade host immune response and suggest a basis for increasing efficacy of drugs by targeting these stress responses to modulate or increase killing activity of current drugs in conjunction with natural immune peptides.