Characterization of the genomic instabilities of sporadic colon cancer
Darbary, Huferesh K.
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Genomic instability is a hallmark of cancer and includes a range of alterations to the genome such as chromosomal alterations, intrachromosomal alterations and epigenetic alterations. Various forms of genomic instability have been characterized. Uniparental chromosomes are found to occur in sporadic colon cancer, chromosomes 14 and 18 demonstrate coordinate presence of uniparentalism. Imprinted genes are not implicated in the selection of the retained and re-duplicated allele. Genomic regions on chromosomes 14 and 22 that include BCR and ABL genes are associated with a genome-wide increase in instability, as are regions on chromosome 7 and 13 in patients with a smoking history. Studies for the TGFBR1 gene, containing a 9A or 6A (alanine) polymorphism indicates a greater age of onset and lesser genomic instability associated in patients carrying the heterozygous 9A/6A form.