Cigarette smoking and colorectal cancer: A case-control study
Peppone, Luke Joseph
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Previous studies have shown that cigarette smoking increases one's risk of colorectal polyps but studies on smoking and colorectal cancer are not clear. It appears that additional research is needed to clarify the relationship. It was hypothesized those with the highest smoking exposure would have the highest risk of colorectal cancer. This study used data from the RPMI Data Series. The findings of this study point to a lack of an association between overall colorectal cancer among persons who were heavy, long-term cigarette smokers. No association was observed between proximal and distal colon cancer among those with the highest exposure to cigarettes. There may be a small increased risk in rectal cancer among participants who were heavy, long-term smokers, especially amongst men (adjOR = 1.45; 95%CI = 0.96-2.19 for >45 pack-years). The results were consistent with a lack of significant findings of similar studies done in the same time period.