The role of Brain-Derived Neurotrophic Factor (BDNF) in cognition, depression and personality in multiple sclerosis
MetadataShow full item record
Past research has indicated that a single nucleotide polymorphism (Val66Met) may play a role in the cognitive, psychiatric, and personality outcomes of patients diagnosed with multiple sclerosis. The present study included 233 MS participants who had completed genetic and neuropsychological testing. Analysis revealed a significant association between Val66Met type and the personality construct Conscientiousness. No other outcome was significantly associated with the Val66Met type. It was concluded that Val66Met may be one component in a complex interaction of genetic and environmental factors that place MS patients at risk for cognitive and psychiatric difficulties. Recommendations for future investigations are discussed.