Feature-based bio-mimetic modeling of heterogeneous scaffolds for improved tissue engineering
Kale, Sameer M.
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In this research, a novel feature-based bio-modeling of three dimensional (3D) tissue scaffolds with controlled spatial distribution of cells and growth factors is presented for improved wound healing and tissue engineering. By incorporating a controlled release of bioactive molecules in tissue scaffolds, such as natural growth factors and proteins, the proliferation and migration of cells on advanced biospecific materials can be controlled. Such controlled delivery of combinations of growth factors and proteins from scaffolds with different release kinetics improves wound healing and tissue regeneration. Therefore, we use a heterogeneous scaffold modeling approach that incorporates spatial and temporal distribution of bioactive molecules over the regenerating tissues. The presented methodology uses biological features or boundaries of the regenerating area to govern the growth factor and protein distribution functions. Feature-based bio-mimetic modeling and morphological blending methods are developed to model 3D heterogeneous scaffolds with growth factors and proteins. The modeled heterogeneous scaffolds could be used for layer by layer scaffold fabrication. The developed algorithms are implemented computationally and several illustrative examples of heterogeneous scaffolds with bioactive molecules for soft tissue and hard tissue engineering are also presented in this research. Keywords: Tissue engineering, feature based design, heterogeneous scaffolds.