Evaluation of a series of antibodies to distinguish the ovarian surface epithelium vs fallopian tube as the origin of serous papillary carcinoma
Janik, Laura Kathleen
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Verifying the cell of origin for a tumor is important in determining a diagnosis as well as treatment for a patient. However the origin is frequently obscured, especially in tumors that metastasize rapidly. This is particularly true in the most common type of ovarian carcinoma, serous papillary carcinoma (SPC). The cell of origin for SPC has remained controversial between the traditional theory that the origin is the ovarian surface epithelium (OSE) and the more recent idea that the origin is the fallopian tube (FT). If SPC originates in the FT, there may be similarities between the protein expression patterns of both tissues. Using normal OSE, normal FT, and SPC tissue, we tested immunohistochemical expression profiles of seven proteins to determine if SPC patterns were similar to those of OSE or FT. We used antibodies to SLPI, Oviductin, AMY2B, Fractalkine, HOXA9, HMGA, and YKL-40 to test expression. All of the proteins except HOXA9 and YKL-40 tested negative in OSE and positive in FT. However in SPC, all of these proteins showed variable expressions suggesting a mixed site of tumor origin. Further evaluation of these proteins and others may be beneficial in determining the definitive site of SPC origin.