Effect of aerobic exercise training on adipose tissue hypoxia and inflammation in obesity
DiSanzo, Beth L.
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Background . Current research has begun to examine adipose hypoxia as a possible mechanism for obesity-related chronic inflammation. Purpose . The purpose of this study was to investigate the effects of aerobic exercise training on adipose tissue hypoxia and inflammation in obese rats. Methods . Twenty-three obese and lean Zucker rats received either 8 weeks of aerobic exercise training or sedentary lifestyle. Epididymal adipose tissue samples were collected for analysis. Results . Adipose capillary density (P<.05) was higher, whereas body weight (P<.05), adipose lactate (P<.05) and monocyte chemoattractant protein-1MCP-1), (P<.05) were lower in the exercise training versus sedentary group in obese rats. Conclusion . These results show that aerobic exercise training may be an effective way to increase capillary density and decrease adipose tissue hypoxia and inflammation in obesity.