Browsing 2014 UB Theses and Dissertations in the Proquest database by Subject "Cancer"
Now showing items 1-4 of 4
Both FLT3-ITd and NPM1 mutations are associated with decreased MLLT3 mRNA expression in acute myeloid leukemia (2014)BACKGROUND: Acute myeloid leukemia (AML) is a molecularly heterogeneous disease characterized by the accumulation of acquired somatic genetic alterations. The most clinically relevant gene mutations include internal tandem ...
FACT is an accelerator of tumorigenesis, a marker of aggressive, undifferentiated cancers, and a potential therapeutic target (2014)Facilitates Chromatin Transcription (FACT) is a heterodimeric complex of subunits SSRP1 and Spt16 that is involved in chromatin remodeling during transcription, replication, and DNA repair. FACT was thought to be ubiquitously ...
Molecular mechanisms by which interferon regulatory factor-8 (IRF-8), a member of the IRF family of transcription factors, suppresses tumor progression of both hematopoietic and nonhematopoietic malignancies (2014)It is well recognized that deregulation of certain transcription factors is indispensable during tumor progression. Identification and characterization of these genes are therefore fundamental requirements to inhibit the ...
(2014)Abstract removed at author's request.