In situ expression of cytokeratins and Ber-EP4 antigen in ameloblastomas and basal cell carcinomas
Martinez Calixto, Luis Edmundo
MetadataShow full item record
Ameloblastomas are odontogenic tumors that sometimes show microscopic features similar manifested by basal cell carcinomas (BCCs). The current literature indicates that anti-cytokeratin reacts in ameloblastomas, but not in BCCs, while Ber-EP4 shows opposite findings. Specific aims . To evaluate the ability of the monoclonal antibodies AE1/AE3 (anti-cytokeratin) and Ber-EP4 (anti-34/39 kD epithelial antigen) to immunohistochemically differentiate BCCs from intraosseous and peripheral ameloblastomas. Materials and methods . 10 peripheral, 11 intraosseous ameloblastomas and 10 BCCs were examined using Ber-EP4 and AE1/AE3 antibodies. Results . AE1/AE3 expression was observed in 90% of cases of BCCs and intraosseous ameloblastomas. Ber-EP4 antigens expression was seen in all cases of BCCs, 30% of intraosseous ameloblastomas and 40% of peripheral ameloblastomas. Conclusions . Our study revealed a heretofore, unrecognized expression of the Ber-EP4 antigen in some intraosseous and peripheral ameloblastomas. Our study indicates that the AE1/AE3 and Ber-EP4 probes are not able to immunohistochemically separate ameloblastomas from BCCs.